The E-Cadherin Antibody from MyBioSource.com is a Mouse Monoclonal antibody to CDH1. This antibody recognizes Human, and Mouse antigen. The E-Cadherin Antibody has been validated for the following applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, and Western Blot.
Description
E-cadherin (epithelial) is the most well-studied member of the cadherin family. It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin. The intracellular domain contains a highly-phosphorylated region vital to beta-catenin binding and, therefore, to E-cadherin function. Loss of E-cadherin function or expression has been implicated in cancer progression and metastasis. E-cadherin downregulation decreases the strength of cellular adhesion within a tissue, resulting in an increase in cellular motility. This in turn may allow cancer cells to cross the basement membrane and invade surrounding tissues. E-cadherin is also used by pathologists to identify different kinds of breast cancer